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The Effect of Elevated Temperature on Carbon Monoxide-Induced Incapacitation

Federal Aviation Administration Civil Aeromedical Institute Toxicology and Accident Research Laboratory P.O. Box 25082, AAM-613 Oklahoma City, OK 73125

Boyd R. Endecott

Federal Aviation Administration Civil Aeromedical Institute Toxicology and Accident Research Laboratory P.O. Box 25082, AAM-613 Oklahoma City, OK 73125

Laboratory rats were exposed to experimental concentrations of carbon monoxide in air at ambient temperature, to elevated temperature at mospheres from 40°C to 60°C, and to selected CO concentrations in 40-60°C whole-body environments. Incapacitating potency was evaluated by measuring time-to-incapacitation as a function of CO concentration and/or temperature. Incapacitation occurred earlier when CO inhalation was combined with elevated temperature than when the same parameters were applied individ ually ; a fractionally additive effect was noted. An empirical equation was derived for predicting time-to-incapacitation from CO concentration and tem perature data.

Key Words: Carbon monoxide • thermal effects • time-to-incapacitation • hyperthermia.

Journal of Fire Sciences, Vol. 9, No. 4, 296-310 (1991)
DOI: 10.1177/073490419100900405


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