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Journal of Fire Sciences
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Relative Inhalation Toxicity in Rats of Pyrolysis Products from Polymeric Materials

Ravindra R. Raje

A. & M. S. College of Pharmacy & Health Sciences Long Island University Brooklyn, NY 11201

Leo Greenberg

A. & M. S. College of Pharmacy & Health Sciences Long Island University Brooklyn, NY 11201

Twenty-eight polymeric materials used in the manufacture of transit equipment were evaluated for relative inhalation toxicity. 10 g of each were pyrolysed at 450, 550, 650, 750, and 850°C and the pyrolysis products were allowed to enter a 225 L cylindrical plexiglass chamber containing a cir cular, chambered unit rotating at 3 rpm. The system was semi-closed with con stant fresh air intake and recirculation of pyrolysis products. From initial py rolysis experiments without rats, using gas chromatographic analysis at 2, 4, 6, 8, 12, 16, 20, and 30 minutes, toxicity experiments were carried out at three temperatures for all the polymeric materials. For each toxicity study, four S/D rats, two males and two females, weighing 150 ± 15 g were used. 10 g of test material were used and chamber air analysed for toxic gases at 2, 4, 6, 8, 12, 16, 20, and 30 minutes of the exposure period. Amber fog lights enabled obser vation of time to incapacitation (Ti). The number of animals dying in the cham ber, or within the following week was noted and dead animals autopsied. All the samples were ranked according to (Ti) at different temperatures, and an at tempt made to determine the rank order correlation between (Ti) and carbon monoxide or carbon dioxide.

Journal of Fire Sciences, Vol. 8, No. 5, 331-342 (1990)
DOI: 10.1177/073490419000800502
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