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Journal of Fire Sciences
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Pulmonary Tissue Reactions in Response to Smoke Injury

George V. Alexeeff

Fire Technology Unit Weyerhaeuser Company P.O. Box 188 Longview, Washington 98632

Y. Cherry Lee

Fire Technology Unit Weyerhaeuser Company P.O. Box 188 Longview, Washington 98632

David Thorning

Departments of Pathology Veterans Administration Medical Center and Universaty of Washington Seattle, Washington 98104

Marianne L. Howard

Respiratory Disease Division Departments of Medicine Harborview Medical Center and University of Washington Seattle, Washington 98108

Leonard D. Hudson

Respiratory Disease Division Departments of Medicine Harborview Medical Center and University of Washington Seattle, Washington 98108

Rats were exposed for 30 minutes at the approximate LC50 of Douglas fir (DF), polyvinyl chloride (PVC) or polyisocyanurate foam (PI) smokes produced in a radiant furnace at 2.5 w/cm2. They were sacrificed and examined for respira tory tissue changes at 24 hours following exposure. All smokes produced air way injury. The more extensive airway injury produced by PVC smoke and, in some instances, by PI smoke, involved the entire epithelial surface area of the trachea and the surfaces of lobar and first division sublobar bronchi. The injury produced by DF smoke was concentrated in the proximal one-half of the trachea. The injuries are discussed with respect to potential chemical toxicants.

Key Words: Fire toxicity • smoke toxicity • smoke pathology • airway injury • com bustion toxicology.

Journal of Fire Sciences, Vol. 4, No. 6, 427-442 (1986)
DOI: 10.1177/073490418600400603
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